Asymmetric preparation of antifungal 1-(4 -chlorophenyl)-1-cyclopropyl methanol and 1-(4 -chlorophenyl)-2-phenylethanol. Study of the detoxification mechanism by Botrytis cinerea

Pinedo Rivilla, Cristina; Aleu Casatejada, Josefina; Hernández Galán, Rosario; González Collado, Isidro; Bustillo Pérez, Antonio

doi:10.1016/j.molcatb.2011.02.005

Identificadores

URI: http://hdl.handle.net/10498/17362

DOI: 10.1016/j.molcatb.2011.02.005

ISSN: 1381-1177

Files

Articulo clorofenil.pdf (453.0Kb)

Statistics

View statistics

Metrics and citations

Export

Metadata

Show full item record

Author/s

Pinedo Rivilla, Cristina

; Aleu Casatejada, Josefina

; Hernández Galán, Rosario

; González Collado, Isidro

; Bustillo Pérez, Antonio

Date

2011-02-24

Department

Química Orgánica

Source

Journal of Molecular Catalysis B: Enzymatic, 2011, vol. 70, pp. 61–66

Abstract

Chiral alcohols are important as bioactive compounds or as precursors to such molecules. On the basis of the different antifungal properties of the enantiopure alcohol derivatives of 4-chlorophenyl cyclopropyl ketone and benzyl 4-chlorophenyl ketone, their enantioselective synthesis by chemical and biocatalytic methods was studied. The detoxification pathways by the phytopathogen fungus Botrytis cinerea are reported.

Subjects

Asymmetric preparation; Botrytis cinerea; Lipase; Baker’s yeast; 1-(4 -Chlorophenyl)-1-cyclopropyl; 1-(4 -Chlorophenyl)-2-phenylethanol

UniversidaddeCádiz