• español
    • English
  • Login
  • English 
    • español
    • English

UniversidaddeCádiz

Área de Biblioteca, Archivo y Publicaciones
Communities and Collections
View Item 
  •   RODIN Home
  • Institutos de Investigación
  • Instituto de Investigación en Biomoléculas INBIO
  • Artículos Científicos INBIO
  • View Item
  •   RODIN Home
  • Institutos de Investigación
  • Instituto de Investigación en Biomoléculas INBIO
  • Artículos Científicos INBIO
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

SAR studies of epoxycurcuphenol derivatives on leukemia CT-CD4 cells

Thumbnail
Identificadores

URI: http://hdl.handle.net/10498/20258

DOI: 10.1016/j.bmc.2012.09.042

Files
2012-SAR studies of epoxycurcuphenol derivatives on leukemia CT-CD4 cells.pdf (837.9Kb)
Statistics
View statistics
Metrics and citations
 
Share
Export
Export reference to MendeleyRefworksEndNoteBibTexRIS
Metadata
Show full item record
Author/s
G. Galindo, José L.; Macías, Mariola; González Molinillo, José MaríaAuthority UCA; Muñoz-Suano, Alba; Torres Martínez, AscensiónAuthority UCA; Varela Montoya, Rosa MaríaAuthority UCA; García Cózar, Francisco JoséAuthority UCA; Macías Domínguez, Francisco AntonioAuthority UCA
Date
2012-09
Department
Química Orgánica
Source
Bioorganic & Medicinal Chemistry 20 (2012) 6662–6668
Abstract
Bioactive natural products are a potential source of new pharmaceuticals since they offer new modes of action and more specific activities. The use of derivatization also enables the optimal structure for their biological activity to be determined. In this study several epoxycurcuphenol derivatives were synthesized. The substitution pattern on the aromatic and oxirane rings was varied along with that at the benzylic position and the length of the side chain was altered. These changes were made in order to gain a deeper understanding of the structural requirements for activity. The biological activities of these compounds were evaluated on the human leukemia cell line Jurkat using an antiproliferative assay. The activity results and structural requirements are discussed.
Subjects
antiproliferative bioassay; leukemia cells; Sunflower; Helianthus annuus; Epoxycurcuphenol derivatives; SAR studies
Collections
  • Artículos Científicos [4205]
  • Artículos Científicos INBIO [242]
  • Articulos Científicos Quim. Org. [158]
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This work is under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 Internacional

Browse

All of RODINCommunities and CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

Statistics

View Usage Statistics

Información adicional

AboutDeposit in RODINPoliciesGuidelinesRightsLinksStatisticsNewsFrequently Asked Questions

RODIN is available through

OpenAIREOAIsterRecolectaHispanaEuropeanaBaseDARTOATDGoogle Academic

Related links

Sherpa/RomeoDulcineaROAROpenDOARCreative CommonsORCID

RODIN está gestionado por el Área de Biblioteca, Archivo y Publicaciones de la Universidad de Cádiz

Contact informationSuggestionsUser Support