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Synthesis of Bioactive Speciosins G and P from Hexagonia speciosa

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URI: http://hdl.handle.net/10498/20314

DOI: 10.1021/np500341q

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2014-Synthesis of bioactive speciosins G and P from hexagonia speciosa.pdf (836.9Kb)
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Author/s
Chinchilla Salcedo, NuriaAuthority UCA; González Molinillo, José MaríaAuthority UCA; Macías Domínguez, Francisco AntonioAuthority UCA; Guerrero-Vásquez, Guillermo A
Date
2014-09
Department
Química Orgánica
Source
J. Nat. Prod. 2014, 77, 2029−2036
Abstract
The first total synthesis of speciosins P and G, previously isolated from Hexagonia speciosa, is reported. These compounds have been synthesized by Sonogashira coupling from readily available starting materials. Siccayne was also synthesized from the same starting material in two steps along with a number of other derivatives. The compounds were tested in the wheat coleoptile bioassay. The most active compound was the intermediate 18, followed by 29 and 17. The structural requirements for activity in these compounds are the presence of methoxy groups in the aromatic ring and a formyl or hydroxy group in the side chain.
Subjects
hexagonia speciosa; synthesis; bioactive; bioactivity
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  • Artículos Científicos [4216]
  • Artículos Científicos INBIO [242]
  • Articulos Científicos Quim. Org. [158]
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This work is under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 Internacional

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