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dc.contributor.authorChinchilla Salcedo, Nuria 
dc.contributor.authorGonzález Molinillo, José María 
dc.contributor.authorMacías Domínguez, Francisco Antonio 
dc.contributor.authorGuerrero-Vásquez, Guillermo A
dc.contributor.otherQuímica Orgánicaen_US
dc.date.accessioned2018-04-10T06:50:55Z
dc.date.available2018-04-10T06:50:55Z
dc.date.issued2014-09
dc.identifier.urihttp://hdl.handle.net/10498/20314
dc.description.abstractThe first total synthesis of speciosins P and G, previously isolated from Hexagonia speciosa, is reported. These compounds have been synthesized by Sonogashira coupling from readily available starting materials. Siccayne was also synthesized from the same starting material in two steps along with a number of other derivatives. The compounds were tested in the wheat coleoptile bioassay. The most active compound was the intermediate 18, followed by 29 and 17. The structural requirements for activity in these compounds are the presence of methoxy groups in the aromatic ring and a formyl or hydroxy group in the side chain.en_US
dc.formatapplication/pdfen_US
dc.language.isoengen_US
dc.publisherJournal of Natural Productsen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceJ. Nat. Prod. 2014, 77, 2029−2036en_US
dc.subjecthexagonia speciosaen_US
dc.subjectsynthesisen_US
dc.subjectbioactiveen_US
dc.subjectbioactivityen_US
dc.titleSynthesis of Bioactive Speciosins G and P from Hexagonia speciosaen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen_US
dc.identifier.doi10.1021/np500341q


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This work is under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 Internacional