TiCl4/Et3N‑Mediated Condensation of Acetate and Formate Esters: Direct Access to β‑Alkoxy- and β‑Aryloxyacrylates
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SourceOrganic Letters 2016, 18, 6344−6347
A methodology to build (E)-β-alkoxy- and (E)-β- aryloxyacrylate moieties from acetate and formate esters promoted by the TiCl4/Et3N system is presented. The reaction is compatible with a broad range of structural skeletons and elapses through an unusual condensation pathway. Taking into account the obtained results, we propose a plausible mechanism involving a bimetallic titanium intermediate for this type of transformation.