A Shared Biosynthetic Pathway for Botcinins and Botrylactones Revealed through Gene Deletions
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SourceChemBioChem 2013, 14, 132 – 136
Isotopic labelling experiments and the study of mutants with disrupted genes encoding botcinic acid have revealed a common link in the biosynthesis of the polyketide toxins excreted by Botrytis cinerea: botcinins and botrylactones. Furthermore, the results reported here shed light on the origin of the starter unit, thereby solving a long-standing mystery in the biosynthesis of botcinins.