The Asymmetric Total Synthesis of Cinbotolide: A Revision of the Original Structure

Statistics
Metrics and citations
Share
Metadata
Show full item recordDate
2014-11Department
Química OrgánicaSource
The Journal of Organic Chemistry 2014, 79, 11349−11358Abstract
The structure 3,4-dihydroxy-2,4,6,8-tetramethyldec-8-enolide (1) was assigned to a metabolite of Botrytis cinerea, but the spectra of several synthetic analogues had significant differences from that of 1. Examination of the constituents of a B. cinerea mutant that overproduces polyketides gave sufficient quantities of 1, now named cinbotolide, for chemical transformations. These led to a revised γ-butyrolactone structure for the metabolite. This structure has been confirmed by an asymmetric total synthesis, which also established its absolute configuration.
Collections
- Artículos Científicos [4821]
- Artículos Científicos INBIO [264]
- Articulos Científicos Quim. Org. [174]