Multiple Anticancer Effects of Damsin and Coronopilin Isolated from Ambrosia arborescens on Cell Cultures

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2013Department
Química OrgánicaSource
ANTICANCER RESEARCH 33: 3799-3806 (2013)Abstract
Terpenoids in plants are important sources for drug discovery. In this study, we extracted damsin and coronopilin, two sesquiterpene lactones, from Ambrosia arborescens and examined their anticancer effects on cell cultures. Damsin and coronopilin inhibited cell proliferation, DNA biosynthesis and formation of cytoplasmic DNA histone complexes in Caco-2 cells, with damsin being more potent than coronopilin. Further studies using the luciferase reporter system showed that damsin and coronopilin also inhibited expressions of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription-3 (STAT3), indicating that these sesquiterpenes can interfere with NF- κB and STAT3 pathways. Finally, we examined the effects of two synthetic dibrominated derivatives of damsin, 11α,13- dibromodamsin and 11β,13-dibromodamsin. While bromination appeared to weaken the antiproliferative effects
of damsin, the β epimer had strong inhibitory effects on STAT3 activation. In conclusion, the sesquiterpene lactones
damsin and coronopilin have inhibitory effects on cell proliferation, DNA biosynthesis and NF-κB and STAT3
pathways, thus being potentially important for discovery of drugs against cancer.
Subjects
Ambrosia arborescens; damsin; coronopilin; chemoselective bromination; sesquiterpenes; cell proliferation; STAT3; NF-κB; apoptosisCollections
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