Efficient O-Acylation of Alcohols and Phenol Using Cp2TiCl as a Reaction Promoter
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SourceEuropean Journal of Organic Chemistry. 2016, 3584–3591
A method has been developed for the conversion of primary, secondary, and tertiary alcohols, and phenol, into the corresponding esters at room temperature. The method uses a titanium(III) species generated from a substoichiometric amount of titanocene dichloride together with manganese(0) as a reductant, as well as methylene diiodide. It involves a transesterification from an ethyl ester, or a reaction with an acyl chloride. A radical mechanism is proposed for these transformations.
SubjectsEsters; Acylation; Radical reactions; Halohydrins; Titanium
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