The Gonadotropin-Inhibitory Hormone: What We Know and What We Still Have to Learn From Fish

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2019-02Department
BiologíaSource
Frontiers in Endocrinology - 2019 Volume 10 Article 78Abstract
Gonadotropin-inhibitory hormone, GnIH, is named because of its function in birds and
mammals; however, in other vertebrates this function is not yet clearly established.
More than half of the vertebrate species are teleosts. This group is characterized by
the 3R whole genome duplication, a fact that could have been responsible for the great
phenotypic complexity and great variability in reproductive strategies and sexual behavior.
In this context, we revise GnIH cell bodies and fibers distribution in adult brains of teleosts,
discuss its relationship with GnRH variants and summarize the few reports available
about the ontogeny of the GnIH system. Considering all the information presented in this
review, we propose that in teleosts, GnIH could have other functions beyond reproduction
or act as an integrative signal in the reproductive process. However, further studies are
required in order to clarify the role of GnIH in this group including its involvement in
development, a key stage that strongly impacts on adult life.
Subjects
GnIH; fish; brain; ontogeny; GnRH; growth; reproductionCollections
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