Review of the Effect of Natural Compounds and Extracts on Neurodegeneration in Animal Models of Diabetes Mellitus

Files
Statistics
Metrics and citations
Share
Metadata
Show full item recordDate
2019-05Source
Int. J. Mol. Sci. 2019, 20(10), 2533Abstract
Diabetes mellitus is a chronic metabolic disease with a high prevalence in the Western
population. It is characterized by pancreas failure to produce insulin, which involves high blood
glucose levels. The two main forms of diabetes are type 1 and type 2 diabetes, which correspond
with >85% of the cases. Diabetes shows several associated alterations including vascular dysfunction,
neuropathies as well as central complications. Brain alterations in diabetes are widely studied; however,
the mechanisms implicated have not been completely elucidated. Diabetic brain shows a wide profile
of micro and macrostructural changes, such as neurovascular deterioration or neuroinflammation
leading to neurodegeneration and progressive cognition dysfunction. Natural compounds (single
isolated compounds and/or natural extracts) have been widely assessed in metabolic disorders and
many of them have also shown antioxidant, antiinflamatory and neuroprotective properties at central
level. This work reviews natural compounds with brain neuroprotective activities, taking into account
several therapeutic targets: Inflammation and oxidative stress, vascular damage, neuronal loss or
cognitive impairment. Altogether, a wide range of natural extracts and compounds contribute
to limit neurodegeneration and cognitive dysfunction under diabetic state. Therefore, they could
broaden therapeutic alternatives to reduce or slow down complications associated with diabetes at
central level.
Subjects
type 2 diabetes; inflammation; vascular damage; learning; memory; neuroprotection; natural extract; natural compoundCollections
- Artículos Científicos [4821]
- Articulos Científicos Biomedicina [212]
- Artículos Científicos INIBICA [491]