Plasma 1α-Hydroxycorticosterone as Biomarker for Acute Stress in Catsharks (Scyliorhinus canicula)

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2019-09Source
Front. Physiol. 10:1217Abstract
Glucocorticoids are pleiotropic steroid hormones mediating redistribution of energy.
They induce breakdown of glycogen stores and consequent plasma hyperglycaemia
after stressful situations. Glucocorticoid actions in most vertebrate species are
exerted by cortisol and corticosterone. However, 1a-hydroxycorticosterone is the
dominant corticosteroid hormone in elasmobranchs, though its effects as a
glucocorticoid are unknown. Here we demonstrate, by using ultra-performance
liquid chromatography coupled to tandem mass spectrometry for the quantification
of 1a-hydroxycorticosterone in plasma of the elasmobranch Scyliorhinus canicula,
the response of this hormone to an acute-stress situation and for the first time
its glucocorticoid action in elasmobranchs. After an acute air-exposure challenge,
S. canicula increased plasma levels of 1a-hydroxycorticosterone altogether with
enhanced glycolysis and gluconeogenesis pathways to fuel energy demanding tissues,
such as white muscle, during the first hours after the stress situation. We foresee our
study as a starting point to evaluate stress responses in elasmobranchs, as well as for
future applications in the management of these key ecosystem species.
Subjects
1a-hydroxycorticosterone; glucocorticoid; Scyliorhinus canicula; shark; stressCollections
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