Show simple item record

dc.contributor.authorDomínguez García, Samuel 
dc.contributor.authorGeribaldi Doldán, Noelia 
dc.contributor.authorGómez Oliva, Ricardo 
dc.contributor.authorRuiz Rodríguez, Félix Alejandro 
dc.contributor.authorCarrascal, Livia
dc.contributor.authorBolívar Pérez, Jorge 
dc.contributor.authorVerástegui Escolano, Cristina 
dc.contributor.authorGarcía Alloza, Mónica 
dc.contributor.authorMacías Sánchez, Antonio José 
dc.contributor.authorHernández Galán, Rosario 
dc.contributor.authorNunez Abades, Pedro
dc.contributor.authorCastro González, Carmen 
dc.contributor.otherAnatomía y Embriología Humanaes_ES
dc.contributor.otherBiomedicina, Biotecnología y Salud Públicaes_ES
dc.contributor.otherQuímica Orgánicaes_ES
dc.date.accessioned2020-05-08T08:47:46Z
dc.date.available2020-05-08T08:47:46Z
dc.date.issued2020-04
dc.identifier.issn2041-4889
dc.identifier.urihttp://hdl.handle.net/10498/22906
dc.description.abstractNeural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which unsuccessfully attempt to migrate toward the damaged tissue. Injuries constitute a gliogenic/non-neurogenic niche generated by the presence of anti-neurogenic signals, which impair neuronal differentiation and migration. Kinases of the protein kinase C (PKC) family mediate the release of growth factors that participate in different steps of the neurogenic process, particularly, novel PKC isozymes facilitate the release of the neurogenic growth factor neuregulin. We have demonstrated herein that a plant derived diterpene, (EOF2; CAS number 2230806-06-9), with the capacity to activate PKC facilitates the release of neuregulin 1, and promotes neuroblasts differentiation and survival in cultures of subventricular zone (SVZ) isolated cells in a novel PKC dependent manner. Local infusion of this compound in mechanical cortical injuries induces neuroblast enrichment within the perilesional area, and noninvasive intranasal administration of EOF2 promotes migration of neuroblasts from the SVZ towards the injury, allowing their survival and differentiation into mature neurons, being some of them cholinergic and GABAergic. Our results elucidate the mechanism of EOF2 promoting neurogenesis in injuries and highlight the role of novel PKC isozymes as targets in brain injury regeneration.es_ES
dc.formatapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherNATURE PUBLISHING GROUPes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceCell Death and Disease (2020) 11:262es_ES
dc.titleA novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injurieses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1038/s41419-020-2453-9
dc.relation.projectIDRTI2018-099908-B-C21; BFU2016-75038R; FEDER-ANDALUCIA sol2018-00106647-traes_ES


Files in this item

This item appears in the following Collection(s)

Show simple item record

Atribución 4.0 Internacional
This work is under a Creative Commons License Atribución 4.0 Internacional