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MicroRNAs overexpressed in Crohn's disease and their interactions with mechanisms of epigenetic regulation explain novel aspects of Crohn's disease pathogenesis

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URI: http://hdl.handle.net/10498/24644

DOI: 10.1186/s13148-021-01022-8

ISSN: 1868-7075

ISSN: 1868-7083 (internet)

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Fernández Ponce, Cecilia MatildeAuthority UCA; Navarro Quiroz, Roberto; Díaz Pérez, Anderson; Aroca Martínez, Gustavo; Cadena Bonfanti, Andrés; Acosta Hoyos, Antonio; Gómez Escorcia, Lorena; Hernández Agudelo, Sandra; Orozco Sánchez, Christian; Villarreal Camacho, José; Atencio Ibarra, Linda; Consuegra Machado, José; Espinoza Garavito, Alberto; García Cózar, Francisco JoséAuthority UCA; Navarro Quiroz, Elkin
Date
2021
Department
Biomedicina, Biotecnología y Salud Pública
Source
Clin Epigenet 13, 39 (2021)
Abstract
Background In this review, we were interested to identify the wide universe of enzymes associated with epigenetic modifications, whose gene expression is regulated by miRNAs with a high relative abundance in Crohn's disease (CD) affected tissues, with the aim to determine their impact in the pathogenesis and evolution of the disease. Methods We used HMDD and Bibliometrix R-package in order to identify the miRNAs overexpressed in CD. The identified enzymes associated with epigenetic mechanisms and post-translational modifications, regulated by miRNAs upregulated in CD, were analyzed using String v11 database. Results We found 190 miRNAs with great abundance in patients with CD, of which 26 miRNAs regulate the gene expression of enzymes known to catalyze epigenetic modifications involved in essentials pathophysiological processes, such as chromatin architecture reorganization, immune response regulation including CD4+ T cells polarization, integrity of gut mucosa, gut microbiota composition and tumorigenesis. Conclusion The integrated analysis of miRNAs with a high relative abundance in patients with CD showed a combined and superimposed gene expression regulation of enzymes associated with relevant epigenetic mechanisms and that could explain, in part, the pathogenesis of CD.
Subjects
MicroRNA; Crohn’ s disease; Epigenetic mechanisms; Post-translational modifications; T cells
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  • Artículos Científicos [4849]
  • Articulos Científicos Biomedicina [213]
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Atribución 4.0 Internacional
This work is under a Creative Commons License Atribución 4.0 Internacional

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