Structures, Occurrences and Biosynthesis of 11,12,13-Tri-nor-Sesquiterpenes, an Intriguing Class of Bioactive Metabolites

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2022-03Department
Biomedicina, Biotecnología y Salud Pública; Química OrgánicaSource
Plants, Vol. 11, Núm. 6Abstract
The compounds 11,12,13-tri-nor-sesquiterpenes are degraded sesquiterpenoids which have lost the C-3 unit of isopropyl or isopropenyl at C-7 of the sesquiterpene skeleton. The irregular C-backbone originates from the oxidative removal of a C-3 side chain from the C-15 sesquiterpene, which arises from farnesyl diphosphate (FDP). The C-12 -framework is generated, generally, in all families of sesquiterpenes by oxidative cleavage of the C-3 substituent, with the simultaneous introduction of a double bond. This article reviews the isolation, biosynthesis and biological activity of this special class of sesquiterpenes, the 11,12,13-tri-nor-sesquiterpenes.