RT info:eu-repo/semantics/article
T1 Synthesis of Bioactive Speciosins G and P from Hexagonia speciosa
A1 Chinchilla Salcedo, Nuria
A1 González Molinillo, José María
A1 Macías Domínguez, Francisco Antonio
A1 Guerrero-Vásquez, Guillermo A
A2 Química Orgánica
K1 hexagonia speciosa
K1 synthesis
K1 bioactive
K1 bioactivity
AB The first total synthesis of speciosins P and G, previously isolated from Hexagonia speciosa, is reported. These compounds have been synthesized by Sonogashira coupling from readily available starting materials. Siccayne was also synthesized from the same starting material in two steps along with a number of other derivatives. The compounds were tested in the wheat coleoptile bioassay. The most active compound was the intermediate 18, followed by 29 and 17. The structural requirements for activity in these compounds are the presence of methoxy groups in the aromatic ring and a formyl or hydroxy group in the side chain.
PB Journal of Natural Products
YR 2014
FD 2014-09
LK http://hdl.handle.net/10498/20314
UL http://hdl.handle.net/10498/20314
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 16 ago. 2022