RT journal article
T1 Dynamic risk control by human nucleus accumbens
A1 Nachev, P
A1 López Sosa, Fernando
A1 González Rosa, Javier Jesús
A1 Galarza, A
A1 Avecillas, J
A1 Pineda-Pardo, JA
A1 Lopez-Ibor, JA
A1 Reneses, B
A1 Barcia, Juan A.
A1 Strange, BA
A2 Psicología
K1 decision-making
K1 nucleus accumbens
K1 reward
K1 risk
K1 subcortical electrical stimulation
AB Real-world decisions about reward often involve a complex counterbalance of risk and value. Although the nucleus accumbens has been implicated in the underlying neural substrate, its criticality to human behaviour remains an open question, best addressed with interventional methodology that probes the behavioural consequences of focal neural modulation. Combining a psychometric index of risky decision-making with transient electrical modulation of the nucleus accumbens, here we reveal profound, highly dynamic alteration of the relation between probability of reward and choice during therapeutic deep brain stimulation in four patients with treatment-resistant psychiatric disease. Short-lived phasic electrical stimulation of the region of the nucleus accumbens dynamically altered risk behaviour, transiently shifting the psychometric function towards more risky decisions only for the duration of stimulation. A critical, on-line role of human nucleus accumbens in dynamic risk control is thereby established.
PB Oxford University Press
SN 0006-8950
YR 2015
FD 2015-12-01
LK http://hdl.handle.net/10498/30681
UL http://hdl.handle.net/10498/30681
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 25-may-2026