@misc{10498/17360,
year = {2010},
month = {6},
url = {http://hdl.handle.net/10498/17360},
abstract = {Enantiomerically pure 2-benzylindane derivatives were prepared using biocatalytic methods and their
absolute configuration determined. (1R,2S)-2-Benzylindan-1-ol ((1R,2S)-2) and
(S)-2-benzylindan-1-one ((S)-3) were produced by fermenting baker’s yeast. Lipase-mediated
esterifications and hydrolysis of the corresponding racemic substrates gave rise to the enantiopure
compounds (1S,2R)-2-benzylindan-1-ol ((1S,2R)-2) and (1R,2S)-2-benzylindan-1-ol ((1R,2S)-2),
respectively. The antifungal activity of these products against two strains of the plant pathogen Botrytis
cinerea was tested. The metabolism of anti-(±)-2-benzylindan-1-ol (anti-(±)-2) by B. cinerea as part of
the fungal detoxification mechanism is also described and revealed interesting differences in the genome
of both strains.},
publisher = {Royal Society of Chemistry},
keywords = {anti-2-benzylindane},
keywords = {Biocatalytic},
keywords = {Botrytis cinerea},
title = {Biocatalytic preparation and absolute configuration of enantiomerically pure fungistatic anti-2-benzylindane derivatives. Study of the detoxification mechanism by Botrytis cinerea},
doi = {10.1039/c003938a},
author = {Pinedo Rivilla, Cristina and Aleu Casatejada, Josefina and Grande Benito, Manuel and González Collado, Isidro},
}