@misc{10498/20258,
year = {2012},
month = {9},
url = {http://hdl.handle.net/10498/20258},
abstract = {Bioactive natural products are a potential source of new pharmaceuticals since they offer new modes of
action and more specific activities. The use of derivatization also enables the optimal structure for their
biological activity to be determined. In this study several epoxycurcuphenol derivatives were synthesized.
The substitution pattern on the aromatic and oxirane rings was varied along with that at the benzylic
position and the length of the side chain was altered. These changes were made in order to gain a
deeper understanding of the structural requirements for activity. The biological activities of these compounds
were evaluated on the human leukemia cell line Jurkat using an antiproliferative assay. The activity
results and structural requirements are discussed.},
publisher = {Bioorganic & Medicinal Chemistry},
keywords = {antiproliferative bioassay},
keywords = {leukemia cells},
keywords = {Sunflower},
keywords = {Helianthus annuus},
keywords = {Epoxycurcuphenol derivatives},
keywords = {SAR studies},
title = {SAR studies of epoxycurcuphenol derivatives on leukemia CT-CD4 cells},
doi = {10.1016/j.bmc.2012.09.042},
author = {G. Galindo, José L. and Macías, Mariola and González Molinillo, José María and Muñoz-Suano, Alba and Torres Martínez, Ascensión and Varela Montoya, Rosa María and García Cózar, Francisco José and Macías Domínguez, Francisco Antonio},
}