@misc{10498/20318,
year = {2015},
month = {4},
url = {http://hdl.handle.net/10498/20318},
abstract = {Aims Benzoxazinones with the 4-hydroxy-(2H)-1,4- benzoxazin-3(4H)-one skeleton have been proposed as potentially successful models for the development of novel design leads. D-DIBOA has proven to be the most promising base structure in the search for novel herbicide models based on the benzoxazinone skeleton. The
biodegradation dynamics of D-DIBOA in soil are therefore relevant and are the subject of this study. Methods A previously optimized methodology for the assessment of biodegradation has been applied for the first time to a synthetic benzoxazinone. Results Biodegradability is a characteristic of natural benzoxazinones and a safety requirement for the development of herbicidal chemicals. The biodegradation phenomenon and its consequences for the development of new herbicide models are discussed. The half-life determined for D-DIBOA was much higher than those previously reported for the natural products DIBOA, DIMBOA and their benzoxazolinone derivatives. Conclusions This finding, together with its previously described potent phytotoxicity, suggests that D-DIBOA is a useful candidate for novel herbicide model development. The lactam D-HBOA, which is slightly less phytotoxic than its precursor, was discovered to be the first and principal metabolite resulting from D-DIBOA degradation.},
publisher = {Plant Soil},
keywords = {D-DIBOA},
keywords = {benzoxazinones},
keywords = {degradation study},
keywords = {soil},
keywords = {herbicide models},
title = {Soil biodegradation of a benzoxazinone analog proposed as a natural products-based herbicide},
doi = {10.1007/s11104-015-2485-6},
author = {Oliveros-Bastidas, Alberto and Chinchilla Salcedo, Nuria and Marín Sánchez, David and González Molinillo, José María and Macías Domínguez, Francisco Antonio},
}