@misc{10498/20572,
year = {2013},
url = {http://hdl.handle.net/10498/20572},
abstract = {The asymmetric synthesis of the antibacterial and antitumoral natural compound xylariolide A (1) and five stereoisomers has been achieved. The strategy is based on the onepot epoxidation/lactonisation or dihydroxylation/lactonisation of the hypothetical biosynthetic intermediate xylarioic A acid (8). The absolute configuration of xylariolide A was thus determined to be 3R,4S,5R,1 R,2 R after the synthesis of 1, two epimers, i.e., 1 -epi-xylariolide A (3) and 2 -epi-xylariolide A (4), and three more diastereoisomers 5–7.},
publisher = {Willey},
keywords = {Natural products},
keywords = {Total synthesis},
keywords = {Asymmetric synthesis},
keywords = {Configuration determination},
keywords = {Medicinal chemistry},
keywords = {Lactones},
title = {Stereoselective Synthesis and Absolute Configuration Determination of Xylariolide A},
doi = {10.1002/ejoc.201201526},
author = {Botubol Ares, José Manuel and Macías Sánchez, Antonio José and González Collado, Isidro and Hernández Galán, Rosario},
}