@misc{10498/20576,
year = {2014},
url = {http://hdl.handle.net/10498/20576},
abstract = {The enantioselective synthesis of (2R,3R,4E,8E)-3-hydroxy-2,4,8-trimethyldeca-4,8-dienolide (5) by
ring-closing metathesis is described. This compound is an analogue of 3,4-dihydroxy-2,4,6,8-tetramethyldec-
8-enolide (4) which is a rare 11-membered lactone produced by the fungus, Botrytis cinerea.
Mutasynthetic studies with compound 5 using two mutants of B. cinerea led to the isolation of four new
highly oxygenated 11-membered lactones (11–14) in which compound 5 has been stereoselectively
epoxidized and hydroxylated at sites that were not easily accessible by classical synthetic chemistry.},
publisher = {The Royal Society of Chemistry},
title = {Exploring mutasynthesis to increase structural diversity in the synthesis of highly oxygenated polyketide lactones},
doi = {10.1039/c4ob00717d},
author = {Botubol Ares, José Manuel and Durán Peña, María Jesús and Macías Sánchez, Antonio José and Hanson, J. R. and González Collado, Isidro and Hernández Galán, Rosario},
}