@misc{10498/20582, year = {2015}, url = {http://hdl.handle.net/10498/20582}, abstract = {Solvent-free desymmetrisation of a meso-dialdehyde with chiral alcohols, led to preparation of 4- silyloxy-6-alkyloxytetrahydro-2H-pyran-2-one derivatives with a 96% de. This methodology, which yields the corresponding methyl nor-mevaldates with 99% ee, has been applied to the enantioselective synthesis of the ( )-(R) and (þ)-(S) nor-mevalonic acid lactones.}, publisher = {Elsevier}, keywords = {Botrytis cinerea}, keywords = {Desymmetrisation}, keywords = {meso-Dialdehyde}, keywords = {Nor-methyl mevaldate}, title = {Diastereoselective and enantioselective preparation of nor-mevaldic acid surrogates through desymmetrisation methodology. Enantioselective synthesis of (+) and (-) nor-mevalonic lactones}, doi = {10.1016/j.tet.2015.08.010}, author = {Botubol Ares, José Manuel and Durán Peña, María Jesús and Hernández Galán, Rosario and González Collado, Isidro and M. Harwood, Laurence and Macías Sánchez, Antonio José}, }