@misc{10498/20586,
year = {2015},
url = {http://hdl.handle.net/10498/20586},
abstract = {Solvent-free desymmetrisation of meso-dialdehyde 1 with chiral 1-phenylethan-1-ol, led to preparation of 4-silyloxy-6-alkyloxytetrahydro-2H-pyran-2-one (+)-3a with a 96:4 dr Deprotected lactone (+)-19a and the related racemic lactones 16a–18a present a lactone moiety resembling the natural substrate of HMG-CoA reductase and their antifungal properties have been evaluated against the phytopathogenic fungi Botrytis cinerea and Colletotrichum gloeosporioides. These compounds were selectively active against B. cinerea, while inactive against C. gloeosporioides.},
publisher = {Elsevier},
keywords = {Antifungal agents},
keywords = {Desymmetrisation},
keywords = {Lactones},
keywords = {nor-Methyl mevaldate},
keywords = {Statins},
title = {nor-Mevaldic acid surrogates as selective antifungal agent leads against Botrytis cinerea. Enantioselective preparation of 4-hydroxy-6-(1-phenylethoxy)tetrahydro-2H-pyran-2-one},
doi = {10.1016/j.bmc.2015.04.048},
author = {Botubol Ares, José Manuel and Durán Peña, María Jesús and Hernández Galán, Rosario and González Collado, Isidro and M. Harwood, Laurence and Macías Sánchez, Antonio José},
}