@misc{10498/22139,
year = {2019},
month = {10},
url = {http://hdl.handle.net/10498/22139},
abstract = {A series of pyrazolo-fused 4-azafluorenones (indeno[1,2-b]pyrazolo[4,3-e]pyridines, IPP)
were synthesized via the three-component reaction between arylaldehydes, 3-methyl-1H-pyrazol-
5-amine and 1,3-indanedione in an ionic liquid as a catalyst at room temperature. The applied synthetic
route has the advantages of easy work-up under mild reaction conditions presenting moderate
yields and an environmentally benign procedure. A theoretical study based on conceptual-density
functional theory has been done, bond reactivity indices have been calculated and an electrophilic
and nucleophilic character of localized orbitals has been determined to analyze the possible
electronic mechanisms.},
publisher = {MDPI},
keywords = {ionic liquid},
keywords = {condensation},
keywords = {4-azafluorenones},
keywords = {ultrasound},
keywords = {reaction mechanism},
keywords = {mass spectrometry},
keywords = {DFT studies},
title = {Synthesis of Pyrazolo-Fused 4-Azafluorenones in an Ionic Liquid. Mechanistic Insights by Joint Studies Using DFT Analysis and Mass Spectrometry},
doi = {10.3390/catal9100820},
author = {Polo, Efraín and Arce-Parada, Valentina and López-Cortés, Xaviera A. and Sánchez Márquez, Jesús and Morales-Bayuelo, Alejandro and Forero-Doria, Oscar and Gutiérrez, Margarita},
}