@misc{10498/22355,
year = {2020},
month = {1},
url = {http://hdl.handle.net/10498/22355},
abstract = {Background: Myocardial function in very-low-birth-weight infants (VLBWIs) develops during early postnatal life, but different patterns of temporal evolution that might be related to the development of bronchopulmonary dysplasia (BPD) are not completely understood. Methods: A prospective cohort study including VLBWIs admitted to our NICU from January 2015 to 2017 was conducted. Plasma N-terminal pro B type natriuretic peptide (NTproBNP) levels were measured, and echocardiograms were performed at 24 and 72 h of life and weekly thereafter until 36 weeks of postmenstrual age (PMA). We measured the tricuspid annular plane systolic excursion (TAPSE) by M-mode; the lateral tricuspid E', A', and S' waves; and the myocardial performance index (MPI) by tissue doppler imaging (TDI). The subjects were divided into non-BPD and BPD groups. Results: We included 101 VLBWIs. The TAPSE and E', A', and S' waves increased while MPI-TDI decreased over time. Birth gestational age (GA) and postnatal PMA impacted these parameters, which evolved differently in those who developed BPD compared to those in the non-BPD group. The NTproBNP levels at 14 days of life and different echocardiographic parameters were associated with the development of BPD in different multivariate models. Conclusion: TAPSE and TDI values depend on GA and PMA and follow a different temporal evolution that is related to the later development of BPD. Combined biochemical and echocardiographic biomarkers can help identify which VLBWIs are at higher risk of developing BDP.},
publisher = {FRONTIERS MEDIA SA},
keywords = {bronchopulmonary dysplasia},
keywords = {preterm infants},
keywords = {myocardial function},
keywords = {N-terminal pro B type natriuretic peptide},
keywords = {tissue doppler imaging},
keywords = {targeted neonatal echocardiography},
keywords = {biomarkers},
keywords = {tricuspid annular plane systolic excursion},
title = {Myocardial Function Maturation in Very-Low-Birth-Weight Infants and Development of Bronchopulmonary Dysplasia},
doi = {10.3389/fped.2019.00556},
author = {Méndez Abad, Paula and Zafra Rodríguez, Pamela and Lubián López, Simón Pedro and Benavente Fernández, Isabel},
}