@misc{10498/24069,
year = {2020},
month = {10},
url = {http://hdl.handle.net/10498/24069},
abstract = {This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)(T3vsT1) = 0.44; 95% confidence interval (CI) = 0.30-0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49-0.90) and arachidonic to dihomo-gamma-linolenic acid ratio (OR (T3vsT1) = 0.64; 95% CI = 0.48-0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20-2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12-2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14-2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45-2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.},
publisher = {MDPI},
keywords = {breast neoplasm},
keywords = {breast cancer subtypes},
keywords = {desaturation indices},
keywords = {fats},
keywords = {EpiGEICAM},
title = {Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype},
doi = {10.3390/nu12103132},
author = {Lope, Virginia and Guerrero-Zotano, Ángel and Casas, Ana and Baena Cañada, José Manuel and Bermejo, Begoña and Pérez-Gómez, Beatriz and Criado-Navarro, Inmaculada and Antolín, Silvia and Sánchez-Rovira, Pedro and Ramos-Vázquez, Manuel and Antón, Antonio and Castelló, Adela and García-Sáenz, José Ángel and Muñoz, Montserrat and de Juan, Ana and Andrés, Raquel and Llombart-Cussac, Antonio and Hernando, Blanca and Franquesa, Rosa María and Caballero, Rosalia and Priego-Capote, Feliciano and Martín, Miguel and Pollán, Marina},
}