@misc{10498/24468,
year = {2021},
month = {1},
url = {http://hdl.handle.net/10498/24468},
abstract = {Roux en Y Gastric bypass is the gold standard surgical method in bariatric surgery, with a severe improvements in the Type 2 Diabetic mellitus. But, many patients used to relapse to the diabetic status five years after this aggressive surgical procedure. We focused on the changes in the beta-cell population and absorptive intestinal consequences after RYGB in a healthy non-obese animal model after a long survival period. To our purpose, we used three Wistar rat groups: RYGB-operated, surgical control (Sham) and fasting control. We measured: alfa-cell and beta-cell mass; transcription -Arx, Pdx-1 and Pax6- and proliferation –Pdx-1- factors; glucose tolerance and insulin release after oral glucose tests; histological adaptive changes in jejunum and intestinal glucose transporter.},
keywords = {beta-cells},
keywords = {pancreas},
keywords = {glucagon},
keywords = {Roux-Y gastric bypass},
keywords = {incretines},
keywords = {cellular differentiation},
title = {The long-term failure of RYGB surgery in T2DM improvement is related to hyperinsulinism.},
author = {Pérez Arana, Gonzalo Martín and Prada Oliveira, José Arturo},
}