@misc{10498/24795,
year = {2021},
month = {3},
url = {http://hdl.handle.net/10498/24795},
abstract = {Diabetic retinopathy (DR) is one of the most common complications of Diabetes Mellitus (DM) and is directly associated with inflammatory processes. Currently, neuro-inflammation is considered an early event in DR and proceeds via microglia polarization. A hallmark of DR is the presence of retinal reactive gliosis. Here we report the beneficial effect of (S (S),1R)-1-docecylsulfiny-5N,6O-oxomethylidenenojirimycin ((Ss)-DS-ONJ), a member of the sp(2)-iminosugar glycolipid (sp(2)-IGL) family, by decreasing iNOS and inflammasome activation in Bv.2 microglial cells exposed to pro-inflammatory stimuli. Moreover, pretreatment with (Ss)-DS-ONJ increased Heme-oxygenase (HO)-1 as well as interleukin 10 (IL10) expression in LPS-stimulated microglial cells, thereby promoting M2 (anti-inflammatory) response by the induction of Arginase-1. The results strongly suggest that this is the likely molecular mechanism involved in the anti-inflammatory effects of (S (S))-DS-ONJ in microglia. (S (S))-DS-ONJ further reduced gliosis in retinal explants from type 1 diabetic BB rats, which is consistent with the enhanced M2 response. In conclusion, targeting microglia polarization dynamics in M2 status by compounds with anti-inflammatory activities offers promising therapeutic interventions at early stages of DR.},
publisher = {FRONTIERS MEDIA SA},
keywords = {sp(2)-iminosugar glycolipids},
keywords = {diabetic retinopathy},
keywords = {microglia},
keywords = {immunomodulation},
keywords = {M2 response},
title = {Anti-Inflammatory (M2) Response Is Induced by a sp(2)-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy},
doi = {10.3389/fimmu.2021.632132},
author = {Cano-Cano, Fátima and Alcalde-Estévez, Elena and Gómez Jaramillo, María Laura and Iturregui, Marta and Sánchez-Fernández, Elena M. and García-Fernández, José M. and Ortiz Mellet, Carmen and Campos Caro, Antonio and López Tinoco, Cristina and Aguilar Diosdado, Manuel and Valverde, Ángela M. and Arroba Espinosa, Ana Isabel},
}