@misc{10498/25139,
year = {2021},
month = {5},
url = {http://hdl.handle.net/10498/25139},
abstract = {Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors. This was a prospective observational study carried out in 78 centers (Spanish Obstetric Emergency Group) with a cohort of 1347 SARS-CoV-2 PCR-positive pregnant women registered consecutively between 26 February and 5 November 2020, and a concurrent sample of PCR-negative mothers. The patients' information was collected from their medical records, and the association of SARS-CoV-2 and perinatal outcomes was evaluated by univariable and multivariate analyses. The data from 1347 SARS-CoV-2-positive pregnancies were compared with those from 1607 SARS-CoV-2-negative pregnancies. Differences were observed between both groups in premature rupture of membranes (15.5% vs. 11.1%, p < 0.001); venous thrombotic events (1.5% vs. 0.2%, p < 0.001); and severe pre-eclampsia incidence (40.6 vs. 15.6%, p = 0.001), which could have been overestimated in the infected cohort due to the shared analytical signs between this hypertensive disorder and COVID-19. In addition, more preterm deliveries were observed in infected patients (11.1% vs. 5.8%, p < 0.001) mainly due to an increase in iatrogenic preterm births. The prematurity in SARS-CoV-2-affected pregnancies results from a predisposition to end the pregnancy because of maternal disease (pneumonia and pre-eclampsia, with or without COVID-19 symptoms).},
publisher = {MDPI},
keywords = {SARS-CoV-2},
keywords = {coronavirus},
keywords = {COVID-19},
keywords = {pregnancy},
keywords = {delivery},
keywords = {perinatal outcomes},
keywords = {premature birth},
keywords = {maternal complications},
title = {Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study},
doi = {10.3390/v13050853},
author = {Cruz Melguizo, Sara and de la Cruz Conty, María Luisa and Carmona Payán, Paola and Abascal-Saiz, Alejandra and Pintando Recarte, Pilar and González Rodríguez, Laura and Cuenca Marín, Celia and Martínez Varea, Alicia and Oreja Cuesta, Ana Belén and Prats Rodríguez, Pilar and Fernández Buhigas, Irene and Rodríguez Gallego, María Victoria and Fernández Alonso, Ana María and López Pérez, Rocío and Broullon Molanes, José Román and Encinas Pardilla, María Begoña and Ramírez Gómez, Mercedes and Gimeno Gimeno, María Joaquina and Sánchez Muñoz, Antonio and Martínez-Pérez, Oscar and Spanish Obstetric Emergency Group (S.O.E.G.)},
}