@misc{10498/25203,
year = {2021},
month = {5},
url = {http://hdl.handle.net/10498/25203},
abstract = {Poly(D,L,-lactide-co-glycolide) (PLGA) foam samples impregnated with rutin were successfully
produced by supercritical foaming processes. A number of parameters such as pressure
(80–200 bar), temperature (35–55  C), depressurization rate (5–100 bar/min), ratio lactide:glycolide of
the poly(D,L,-lactide-co-glycolide) (50:50 and 75:25) were studied to determine their effect on the expansion
factor and on the glass transition temperature of the polymer foams and their consequences
on the release profile of the rutin entrapped in them. The impregnated foams were characterized by
scanning electron microscopy, differential scanning calorimetry, and mercury intrusion porosimetry.
A greater impregnation of rutin into the polymer foam pores was observed as pressure was increased.
The release of rutin in a phosphate buffer solution was investigated. The controlled release tests
confirmed that the modification of certain variables would result in considerable differences in the
drug release profiles. Thus, five-day drug release periods were achieved under high pressure and
temperature while the depressurization rate remained low.},
organization = {This research was funded by Spanish Ministry of Economy, Industry and Competitiveness: CTQ2017-86661-R.},
publisher = {MDPI},
keywords = {PLGA},
keywords = {supercritical CO2 foaming},
keywords = {rutin},
keywords = {scaffolds},
keywords = {release profile},
title = {Determining the Optimal Conditions for the Production by Supercritical CO2 of Biodegradable PLGA Foams for the Controlled Release of Rutin as a Medical Treatment},
doi = {10.3390/polym13101645},
author = {Valor López, Diego and Montes Herrera, Antonio and Monteiro, Marilia and García Casas, Ignacio and Pereyra López, Clara María and Martínez de la Ossa Fernández, Enrique José},
}