@misc{10498/25878,
year = {2021},
month = {8},
url = {http://hdl.handle.net/10498/25878},
abstract = {C-17-sesquiterpenoids are a group of natural products that have been recently discovered. These compounds have the peculiarity of lacking the alpha,beta-methylene butyrolactone system, which is known to be quite relevant for many of the biological activities reported for sesquiterpene lactones. Unfortunately, the biological interest of C-17-sesquiterpenoids has not been studied in-depth, mainly due to the poor isolation yields in which they can be obtained from natural sources. Therefore, in order to allow a deeper study of these novel molecules, we have worked out a synthetic pathway that provides C-17-sesquiterpenoids in enough quantities from easily accessible sesquiterpene lactones to enable a more thorough investigation of their bioactivities. With this synthesis method, we have successfully synthesized, for the first time, three natural C-17-sesquiterpenoids, pertyolides A, B, and C, with good overall yields. Furthermore, we have also evaluated their phytotoxicity against etiolated wheat coleoptiles and corroborated that pertyolides B and C present strong phytotoxic activity.},
organization = {This research was supported by the Ministerio de Economia, Industria y Competitividad (MINEICO), Spain, AGL2017-88083-R.},
publisher = {AMER CHEMICAL SOC},
title = {Synthesis of Pertyolides A, B, and C: A Synthetic Procedure to C-17-Sesquiterpenoids and a Study of Their Phytotoxic Activity},
doi = {10.1021/acs.jnatprod.1c00396},
author = {Cárdenas, David M. and Rial Cumbrera, Carlos and Varela Montoya, Rosa María and González Molinillo, José María and Macías Domínguez, Francisco Antonio},
}