@misc{10498/26422,
year = {2021},
month = {12},
url = {http://hdl.handle.net/10498/26422},
abstract = {Brown algae of the Family Dictyotaceae produce an array of structurally diverse terpenoids,
whose biomedical potential in the anti-inflammatory area has been scarcely explored. Herein, the
chemical study of the alga Rugulopteryx okamurae has led to the isolation of ten new diterpenoids:
rugukadiol A (1), rugukamurals A–C (2–4), and ruguloptones A–F (6–10). The structures of the
new compounds were established by spectroscopic means. Compound 1 exhibits an unprecedented
diterpenoid skeleton featuring a bridged tricyclic undecane system. Compounds 2–10 belong to the
secospatane class of diterpenoids and differ by the oxygenated functions that they contain. In antiinflammatory
assays, the new diterpenoid 1 and the secospatanes 5 and 10 significantly inhibited the
production of the inflammatory mediator NO in LPS-stimulated microglial cells Bv.2 and macrophage
cells RAW264.7. Moreover, compounds 1 and 5 were found to strongly inhibit the expression of Nos2
and the pro-inflammatory cytokine Il1b in both immune cell lines.},
publisher = {MDPI},
keywords = {diterpenoids},
keywords = {brown algae},
keywords = {Rugulopteryx okamurae},
keywords = {anti-inflammatory},
keywords = {nitric oxide},
keywords = {cytokine},
keywords = {microglia},
keywords = {macrophages},
keywords = {invasive algae},
title = {Diterpenoids from the Brown Alga Rugulopteryx okamurae and Their Anti-Inflammatory Activity},
doi = {10.3390/md19120677},
author = {Cuevas, Belén and Arroba Espinosa, Ana Isabel and Reyes Jiménez, Carolina de los and Gómez Jaramillo, María Laura and González Montelongo, María del Carmen and Zubía Mendoza, Eva},
}