@misc{10498/27072,
year = {2022},
month = {4},
url = {http://hdl.handle.net/10498/27072},
abstract = {IntroductionGalectin-3 (Gal-3) is an inflammatory marker associated with the development and progression of heart failure (HF). A close relationship between Gal-3 levels and renal function has been observed, but data on their interaction in patients with acute HF (AHF) are scarce. We aim to assess the prognostic relationship between renal function and Gal-3 during an AHF episode. Materials and MethodsThis is an observational, prospective, multicenter registry of patients hospitalized for AHF. Patients were divided into two groups according to estimated glomerular filtration rate (eGFR): preserved renal function (eGFR >= 60 mL/min/1.73 m(2)) and renal dysfunction (eGFR <60 mL/min/1.73 m(2)). Cox regression analysis was performed to evaluate the association between Gal-3 and 12-month mortality. ResultsWe included 1,201 patients in whom Gal-3 values were assessed at admission. The median value of Gal-3 in our population was 23.2 ng/mL (17.3-32.1). Gal-3 showed a negative correlation with eGFR (rho = -0.51; p < 0.001). Gal-3 concentrations were associated with higher mortality risk in the multivariate analysis after adjusting for eGFR and other prognostic variables [HR = 1.010 (95%-CI: 1.001-1.018); p = 0.038]. However, the prognostic value of Gal-3 was restricted to patients with renal dysfunction [HR = 1.010 (95%-CI: 1.001-1.019), p = 0.033] with optimal cutoff point of 31.5 ng/mL, with no prognostic value in the group with preserved renal function [HR = 0.990 (95%-CI: 0.964-1.017); p = 0.472]. ConclusionsGal-3 is a marker of high mortality in patients with acute HF and renal dysfunction. Renal function influences the prognostic value of Gal-3 levels, which should be adjusted by eGFR for a correct interpretation.},
publisher = {FRONTIERS MEDIA SA},
keywords = {acute heart failure (AHF)},
keywords = {galectin-3 (Gal-3)},
keywords = {cardiorenal syndrome (CRS)},
keywords = {renal function},
keywords = {prognosis},
title = {Renal Function Impact in the Prognostic Value of Galectin-3 in Acute Heart Failure},
doi = {10.3389/fcvm.2022.861651},
author = {Caravaca Perez, Pedro and González-Juanatey, José R. and Nuche, Jorge and Matute-Blanco, Lucia and Serrano, Isabel and Martínez-Sellés, Manuel and Vázquez García, Rafael and Martínez Dolz, Luis and Gómez-Bueno, Paloma and Pascual-Figal, Domingo and Crespo-Leiro, Marisa and García-Osuna, Álvaro and Ordoñez-Llanos, Jordi and Cinca Cuscullola, Juan and Guerra, José M. and Delgado, Juan F.},
}