@misc{10498/27161, year = {2022}, month = {1}, url = {http://hdl.handle.net/10498/27161}, abstract = {Loss of follow-up or reinfections hinder the expectations of hepatitis C eradication despite the existence of highly effective treatments. Moreover, the elimination of the infection does not imply the reversion of those chronic alterations derived from the previous infection by hepatitis C virus (HCV). This review analyzes the risk factors associated with loss to follow-up in diagnosis or treatment, and the possibility of reinfection. Likewise, it assesses the residual alterations induced by chronic HCV infection considering the liver alterations (inflammation, fibrosis, risk of decompensation, hepatocellular carcinoma, liver transplantation) and, on the other hand, the comorbidities and extrahepatic manifestations (cryoglobulinemia, non-Hodgkin lymphoma, peripheral insulin resistance, and lipid, bone and cognitive alterations). Peculiarities present in subjects coinfected with human immunodeficiency virus are analyzed in each section.}, publisher = {BAISHIDENG PUBLISHING GROUP INC}, keywords = {Hepatitis C virus}, keywords = {Sustained virological response}, keywords = {Direct antiviral agents}, keywords = {Human immunodeficiency virus}, keywords = {Cirrhosis decompensation}, keywords = {Hepatocarcinoma}, keywords = {Extrahepatic complications}, title = {Hepatitis C: Problems to extinction and residual hepatic and extrahepatic lesions after sustained virological response}, doi = {10.4254/WJH.V14.I1.62}, author = {Cuesta Sancho, Sara and Márquez Coello, María de las Mercedes and Illanes Álvarez, Francisco and Márquez Ruiz, Denisse and Arizcorreta Yarza, Ana and Galán Sánchez, Fátima and Montiel, Natalia and Rodríguez Iglesias, Manuel Antonio and Girón González, José Antonio}, }