@misc{10498/27935,
year = {2022},
month = {7},
url = {http://hdl.handle.net/10498/27935},
abstract = {The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p=0.030). Shorter telomere length was associated with cognitive performance (working memory, r=0.31 p=0.015; verbal fluency, r=0.28 p=0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages.},
publisher = {SPRINGERNATURE},
title = {Epigenetic clocks in relapse after a first episode of schizophrenia},
doi = {10.1038/s41537-022-00268-2},
author = {González Segura, Álex and Prohens, Llucia and Mezquida, G. and Amoretti, Silvia and Bioque, Miquel and Ribeiro, M. and Gurriarán-Bas, Xaquin and Rementería, Lide and Berge, Daniel and Rodriguez-Jimenez, R. and Roldán, Alexandra and Pomarol-Clotet, Edit and Ibáñez, Angela and Usall, J. and García Portilla, María Paz and Cuesta, Manuel J. and Parellada, M. and González-Pinto, A. and Berrocoso Domínguez, Esther María and Bernardo, Miquel and Mas, Sergi and 2EPS group},
}