@misc{10498/27984,
year = {2022},
month = {7},
url = {http://hdl.handle.net/10498/27984},
abstract = {This study aimed to analyze the influence of the peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha (PPARGC1A) gene rs8192678 C > T polymorphism on different health-related parameters in male and female young adults. The PPARGC1A gene rs8192678 polymorphism was ascertained by polymerase chain reaction in 74 healthy adults (28 women; 22.72 +/- 4.40 years) from Andalusia (Spain). Health-related variables included cardiometabolic risk, anthropometry and body composition, biochemical parameters, insulin sensitivity (QUICKI and HOMA-IR indexes), blood pressure (BP) at rest and after exercise, diet, basal metabolism, physical activity, maximal fat oxidation, and cardiorespiratory fitness. Our results showed differences by PPARGC1A gene rs8192678 C > T polymorphism in body mass (p = 0.002), body mass index (p = 0.024), lean body mass (p = 0.024), body fat (p = 0.032), waist circumference (p = 0.020), and BP recovery ratio (p < 0.001). The recessive model (CC vs. CT/TT) showed similar results but also with differences in basal metabolism (p = 0.045) and total energy expenditure (p = 0.024). A genotype*sex interaction was found in the QUICKI index (p = 0.016), with differences between CC and CT/TT in men (p = 0.049) and between men and women inside the CT/TT group (p = 0.049). Thus, the PPARGC1A gene rs8192678 C > T polymorphism is associated with body composition, basal metabolism, total energy expenditure, and BP recovery, where the CC genotype confers a protective effect. Moreover, our study highlighted sexual dimorphism in the influence of PPARGC1A gene rs8192678 C > T polymorphism on the QUICKI index.},
publisher = {FRONTIERS MEDIA SA},
keywords = {genetic association studies},
keywords = {cardiometabolic risk},
keywords = {metabolism},
keywords = {healthy lifestyle},
keywords = {PPARGC1A},
keywords = {caucasian, obesity},
keywords = {physical exercise},
title = {Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults},
doi = {10.3389/fphys.2022.885185},
author = {Montes de Oca García, Adrian and Corral Pérez, Juan and Velázquez Díaz, Daniel and Pérez-Bey, Alejandro and Rebollo Ramos, María and Marín Galindo, Alberto and Gómez-Gallego, Félix and Calderón Domínguez, María and Casals Vázquez, Cristina and Ponce González, Jesús Gustavo},
}