@misc{10498/28743,
year = {2022},
month = {10},
url = {http://hdl.handle.net/10498/28743},
abstract = {The high mortality rate due to COVID-19 has necessitated the mass vaccination against SARS-CoV-2 to induce protective humoral and cellular immunity. (1) Objective: To study the dynamics of SARS-CoV-2-specific B cells after two doses of the Pfizer-BioNTech SARS-CoV-2 vaccine. (2) Methods: Immunophenotyping and cellular cultures were used to determine the kinetics of B-cell subpopulations and vaccine responses in volunteers before and seven days, three months and seven months after the second dose in Spain (n = 19). (3) Results: Seven days after immunisation, memory B cells and plasmablasts expressing receptors for factors implicated in the maturation of plasma cells were augmented in blood. Three months after vaccination, SARS-CoV-2 spike-specific plasmablasts disappeared from circulation while spike-specific memory-B cells circulated, with heterogeneous dynamics among individuals. (4) Conclusion: After vaccination, specific plasmablasts equipped with receptors for maturation factors were quickly generated and disappeared rapidly from the blood, while specific memory B cells circulated for at least seven months.},
publisher = {MDPI},
keywords = {SARS-CoV-2},
keywords = {COVID-19},
keywords = {vaccine immunogenicity},
keywords = {B cell},
keywords = {plasmablast},
keywords = {plasma cell},
title = {Dynamics of B-Cell Responses after SARS-CoV-2 Vaccination in Spain},
doi = {10.3390/vaccines10101615},
author = {San José-Cascón, Miriam and Varga-Martínez, Raquel de la and Campos Caro, Antonio and Rodríguez, Carmen},
}