@misc{10498/29593,
year = {2023},
month = {4},
url = {http://hdl.handle.net/10498/29593},
abstract = {Background: The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. Methods: We did a prospective cohort study across 23 hospitals in Spain. We included patients aged 18 years or older with laboratory-confirmed SARS-CoV-2 infection who were admitted to an intensive care unit between March 16, 2020, and Feb 27, 2021. RNA of the SARS-CoV-2 nucleocapsid region 1 (N1) was quantified in plasma samples collected from patients in the first 48 h following admission, using digital PCR. Patients were grouped on the basis of N1 quantity: VIR-N1-Zero ([removed]2747 N1 copies per mL). The primary outcome was all-cause death within 90 days after admission. We evaluated odds ratios (ORs) for the primary outcome between groups using a logistic regression analysis. Findings: 1068 patients met the inclusion criteria, of whom 117 had insufficient plasma samples and 115 had key information missing. 836 patients were included in the analysis, of whom 403 (48%) were in the VIR-N1-Low group, 283 (34%) were in the VIR-N1-Storm group, and 150 (18%) were in the VIR-N1-Zero group. Overall, patients in the VIR-N1-Storm group had the most severe disease: 266 (94%) of 283 patients received invasive mechanical ventilation (IMV), 116 (41%) developed acute kidney injury, 180 (65%) had secondary infections, and 148 (52%) died within 90 days. Patients in the VIR-N1-Zero group had the least severe disease: 81 (54%) of 150 received IMV, 34 (23%) developed acute kidney injury, 47 (32%) had secondary infections, and 26 (17%) died within 90 days (OR for death 0·30, 95% CI 0·16–0·55; p<0·0001, compared with the VIR-N1-Storm group). 106 (26%) of 403 patients in the VIR-N1-Low group died within 90 days (OR for death 0·39, 95% CI 0·26–0·57; p[removed]},
publisher = {Elsevier},
keywords = {COVID-19},
keywords = {viral R  load},
keywords = {cause death},
title = {Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study},
doi = {10.1016/S2666-5247(23)00041-1},
author = {Bermejo Martin, Jesús F. and García Mateo, Nadia and Motos, Anna and Resino, Salvador and Tamayo, Luis and Ryan Murua, Pablo and Bustamante Munguira, Elena and Gallego Curto, Elena and Úbeda Iglesias, Alejandro and de la Torre, María del Carmen and Estella García, Ángel and Campos Fernández, Sandra and Martínez Varela, Ignacio and Pérez García, Felipe and Socias, Lorenzo and López Messa, Juan and Vidal Cortés, Pablo and Sagredo Meneses, Víctor and González Rivera, Milagros and Carbonell, Nieves and de Gonzalo Calvo, David and Martín Delgado, María Cruz and Valdivia, Luis Jorge and Martín López, Caridad and Jorge García, Ruth Noemí and Maseda, Emilio and Loza Vázquez, Ana and Kelvin, David J. and Barbé, Ferrán and Torres, Antoni and Ortega, Alicia and de la Fuente, Amanda and Almansa, Raquel and Postigo, Tamara and Jorge, Noelia and Tedim, Ana P. and González González, Laura and Sánchez Recio, Lara and Trapiello, Wysali and Berezo, José Ángel and Herrán Monge, Rubén and Blanco, Jesús and Enríquez, Pedro and Martínez, Isidoro and Martín Vicente, María and Muñoz Gómez, María José and Más, Vicente and Vázquez, Mónica and Cano, Olga and Martínez de la Gándara, Amalia and Rodríguez, Covadonga and Andrade, Gloria and Renedo, Gloria and Bustamante Munguira, Juan and Cicuendez Ávila, Ramón and Salgado Villén, María and Berruguilla Pérez, Enrique and Güell, Estel and Casadiego Monachello, Fernando Javier and Recuerda Núñez, María and Sánchez Calvo, Juan Manuel and Peñasco Martín, Yhivian and García Unzueta, María Teresa and Ceccato, Adrián and Fernández Barat, Laia and Bouza Vieiro, María Teresa and Moreno Romero, Ana and Pérez Bastida, Leire and del Río Carbajo, Lorena and Albalá Martínez, Noelia and Gómez, José Manuel and Blasco, María Luisa and Caballero, Jesús and Barberà, Carme and González, Jessica and Nieto, María Teresa and Nieto del Olmo, Jorge and Prol Silva, Estefanía and Canseco Ribas, Joan and Eiros, Jose María},
}