@misc{10498/30350,
year = {2017},
month = {4},
url = {http://hdl.handle.net/10498/30350},
abstract = {Hepatitis C virus (HCV) infection is currently the most important cause of chronic viral
hepatitis in the world and one of the most frequent indications for liver transplantation.
HCV uses different strategies to evade the innate and adaptive immune response,
and this evasion plays a key role in determining viral persistence. Several HCV viral
proteins have been described as immune modulators. In this review, we will focus on
the effect of HCV nucleocapsid core protein in the function of immune cells and its
correlation with the findings observed in HCV chronically infected patients. Effects on
immune cell function related to both extracellular and intracellular HCV core localization
will be considered. This review provides an updated perspective on the mechanisms
involved in HCV evasion related to one single HCV protein, which could become
a key tool in the development of new antiviral strategies able to control and/or eradicate
HCV infection.},
organization = {Ministerio de Educación y Ciencia (España) (SAF2009-09449); Consejería de Salud de la Junta de Andalucía (SAS 111206)},
publisher = {WILEY},
keywords = {exhausted phenotype},
keywords = {HCV},
keywords = {immune evasion},
keywords = {immune tolerance},
keywords = {regulatory T cells},
title = {Immune modulation by the hepatitis C virus core protein},
doi = {10.1111/jvh.12675},
author = {Fernández Ponce, Cecilia Matilde and Domínguez Villar, Margarita and Muñoz Miranda, Juan Pedro and Martínez de Arbulo Echevarría, Miguel and Litrán Ramos, Rocío and Aguado Vidal, Enrique and García Cózar, Francisco José},
}