@misc{10498/31136,
year = {2020},
url = {http://hdl.handle.net/10498/31136},
abstract = {A new manganese(III) complex [MnL1(DCA)(H2O)](H2O), 1, has been prepared using the chelating ligand N,N’-bis(2-hydroxy-3-methoxybenzylidene)-1,2-diaminopropane (H2L1), and characterized by different analytical and spectroscopic techniques. The tetragonally elongated octahedral geometry for the manganese coordination sphere was revealed by X-ray diffraction studies for 1. The antioxidant behavior of this complex and other manganese(III)-salen type complexes was tested through SOD and catalase probes, and through the study of their neuroprotective effects in SH-SY5Y neuroblastoma cells. In this human neuronal model, these model complexes were found to improve cell survival in an oxidative stress model. During studies aimed to getting a better understanding of the kinetics of the processes involved in this antioxidant behavior, an important effect on the solvent in the kinetics of reaction of the complexes with H2O2 was revealed that suggests a change in the mechanism of reaction of the complexes. The kinetic data in methanol and buffered aqueous solutions correlate well with the results of the test of catalase activity, thus showing that the rate determining step in the catalytic cycle corresponds to the initial reaction of the complexes with H2O2.},
publisher = {ELSEVIER},
keywords = {Manganese, oxidative stress},
keywords = {Neuroprotection, Shiff bass},
title = {Salen-manganese complexes for controlling ROS damage: Neuroprotective effects, antioxidant activity and kinetic studies},
doi = {10.1016/J.JINORGBIO.2019.110918},
author = {Rouco, Lara and Liberato González, Andrea and Fernández-Trujillo Rey, María Jesús and Máñez Muñoz, María Ángeles and García Basallote, Manuel and Alvariño, Rebeca and Alfonso, Amparo and Botana, Luis M. and Maneiro, Marcelino},
}