@misc{10498/31202,
year = {2023},
month = {1},
url = {http://hdl.handle.net/10498/31202},
abstract = {It is not known whether sequential outpatient parenteral antimicrobial (OPAT) is as safe and effective as conventional hospitalization in patients with S. aureus bacteremia (SAB). A post-hoc analysis of the comparative effectiveness of conventional hospitalization versus sequential OPAT was performed in two prospective Spanish cohorts of patients with S. aureus bacteremia. The PROBAC cohort is a national, multicenter, prospective observational cohort of patients diagnosed in 22 Spanish hospitals between October 2016 and March 2017. The DOMUS OPAT cohort is a prospective observational cohort including patients from two university hospitals in Seville, Spain from 2012 to 2021. Multivariate regression was performed, including a propensity score (PS) for receiving OPAT, stratified analysis according to PS quartiles, and matched pair analyses based on PS. Four hundred and thirteen patients were included in the analysis: 150 in sequential OPAT and 263 in the full hospitalization therapy group. In multivariate analysis, including PS and center effect as covariates, 60-day treatment failure was lower in the OPAT group than in the full hospitalization group (p < 0.001; OR 0.275, 95%CI 0.129–0.584). In the PS-based matched analyses, sequential treatment under OPAT was not associated with higher 60-day treatment failure (p = 0.253; adjusted OR 0.660; % CI 0.324–1.345). OPAT is a safe and effective alternative to conventional in-patient therapy for completion of treatment in well-selected patients with SAB, mainly those associated with a low-risk source and without end-stage kidney disease.},
publisher = {MDPI},
keywords = {bacteremia},
keywords = {outpatient parenteral antimicrobial therapy},
keywords = {Staphylococcus aureus},
title = {Conventional Hospitalization versus Sequential Outpatient Parenteral Antibiotic Therapy for Staphylococcus aureus Bacteremia: Post-Hoc Analysis of a Multicenter Observational Cohort},
doi = {10.3390/antibiotics12010129},
author = {Castillo Fernández, Nerea and Martínez Pérez-Crespo, Pedro María and Salamanca Rivera, Elena and Herrera Hidalgo, Laura and de Alarcón, Arístides and Navarro Amuedo, María Dolores and Marrodán Ciordia, Teresa and Pérez Rodríguez, María Teresa and Sevilla Blanco, Juan and Jóver Saenz, Alfredo and Fernández Suárez, Jonathan and Armiñanzas Castillo, Carlos and Reguera Iglesias, José María and Natera Kindelán, Clara and Boix Palop, Lucía and León Jiménez, Eva and Galán Sánchez, Fátima and del Arco Jiménez, Alfonso and Bahamonde Carrasco, Alberto and Vinuesa García, David and Smithson Amat, Alejandro and Cuquet Pedragosa, Jordi and Reche Molina, Isabel María and Pérez Camacho, Inés and Merino de Lucas, Esperanza and Gutiérrez Gutiérrez, Belén and Rodríguez Baño, Jesús and López Cortés, Luis Eduardo},
}