@misc{10498/31473,
year = {2023},
url = {http://hdl.handle.net/10498/31473},
abstract = {T cells are crucial players of immune responses by their ability to specifically recognize
foreign, potentially harmful, antigens. To perform such specific recognition, T cells express
at their plasma membrane an antigen receptor called the T cell receptor (TCR) (1–3). The
TCR expressed at the plasma membrane in the majority of T cells is composed by a TCR-a
and TCR-b heterodimer, which is able to recognize a complex formed by an antigenic
peptide coupled to an MHC molecule (pMHC complex). After specific recognition by a
pMHC complex the TCR triggers multiple intracellular signals leading to proliferation,
target cell killing, cytokine secretion, and differentiation into effector T cells. Although our
understanding of the molecular mechanisms governing activation of T cells has
dramatically grown in recent years, there is still much to learn},
publisher = {Frontiers Media SA},
keywords = {binding prediction},
keywords = {machine learning},
keywords = {method},
keywords = {T cell},
keywords = {T cell epitope},
keywords = {TCR (T cell receptor)},
title = {Editorial: Methods in T cell biology: 2022},
doi = {10.3389/FIMMU.2023.1266576},
author = {Aguado Vidal, Enrique and Call, M.E.},
}