@misc{10498/31488,
year = {2023},
url = {http://hdl.handle.net/10498/31488},
abstract = {The biological activity of glucagon has recently been proposed to both stimulate hepatic glucose production and also include a paradoxical insulinotropic effect, which could suggest a new role of glucagon in the pathophysiology type 2 diabetes mellitus (T2DM). An insulinotropic role of glucagon has been observed after bariatric/metabolic surgery that is mediated through the GLP-1 receptor on pancreatic beta cells. This effect appears to be modulated by other members of the proglucagon family, playing a key role in the beneficial effects and complications of bariatric/metabolic surgery. Glucagon serves a dual role after sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). In addition to maintaining blood glucose levels, glucagon exhibits an insulinotropic effect, suggesting that glucagon has a more complex function than simply an “anti-insulin hormone”.},
publisher = {Frontiers Media SA},
keywords = {alpha cell},
keywords = {diabetes},
keywords = {glucagon},
keywords = {glucose},
keywords = {incretin},
keywords = {Roux-en-Y gastric bypass},
keywords = {sleeve gastrectomy},
title = {The role of glucagon after bariatric/metabolic surgery: much more than an “anti-insulin” hormone},
doi = {10.3389/FENDO.2023.1236103},
author = {Pérez Arana, Gonzalo Martín and Díaz Gómez, Alfredo Luis and Bancalero-de los Reyes, José and Gracia Romero, Manuel Ángel and Ribelles García, Antonio and Visiedo García, Francisco Manuel and González Domínguez, Álvaro and Almorza Gomar, David and Prada Oliveira, José Arturo},
}