@misc{10498/31730,
year = {2023},
url = {http://hdl.handle.net/10498/31730},
abstract = {Introduction: Critical COVID-19 survivors have a high risk of respiratory sequelae. Therefore, we aimed to identify key factors associated with altered lung function and CT scan abnormalities at a follow-up visit in a cohort of critical COVID-19 survivors. Methods: Multicenter ambispective observational study in 52 Spanish intensive care units. Up to 1327 PCR-confirmed critical COVID-19 patients had sociodemographic, anthropometric, comorbidity and lifestyle characteristics collected at hospital admission; clinical and biological parameters throughout hospital stay; and, lung function and CT scan at a follow-up visit. Results: The median [p25–p75] time from discharge to follow-up was 3.57 [2.77–4.92] months. Median age was 60 [53–67] years, 27.8% women. The mean (SD) percentage of predicted diffusing lung capacity for carbon monoxide (DLCO) at follow-up was 72.02 (18.33)% predicted, with 66% of patients having DLCO < 80% and 24% having DLCO < 60%. CT scan showed persistent pulmonary infiltrates, fibrotic lesions, and emphysema in 33%, 25% and 6% of patients, respectively. Key variables associated with DLCO < 60% were chronic lung disease (CLD) (OR: 1.86 (1.18–2.92)), duration of invasive mechanical ventilation (IMV) (OR: 1.56 (1.37–1.77)), age (OR [per-1-SD] (95%CI): 1.39 (1.18–1.63)), urea (OR: 1.16 (0.97–1.39)) and estimated glomerular filtration rate at ICU admission (OR: 0.88 (0.73–1.06)). Bacterial pneumonia (1.62 (1.11–2.35)) and duration of ventilation (NIMV (1.23 (1.06–1.42), IMV (1.21 (1.01–1.45)) and prone positioning (1.17 (0.98–1.39)) were associated with fibrotic lesions. Conclusion: Age and CLD, reflecting patients’ baseline vulnerability, and markers of COVID-19 severity, such as duration of IMV and renal failure, were key factors associated with impaired DLCO and CT abnormalities.},
publisher = {Sociedad Española de Neumología y Cirugía Torácica (SEPAR)},
keywords = {COVID-19},
keywords = {CT abnormalities},
keywords = {ICU},
keywords = {Lung function},
keywords = {Sequelae},
title = {Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients},
doi = {10.1016/j.arbres.2022.12.017},
author = {González, Jessica and Batlle, Jordi and Benítez, Iván D. and Torres, Gerard and Santisteve, Sally and Targa, Adriano D.S. and Gort Paniello, Clara and Moncusí Moix, Anna and Aguilà, Maria and Seck, Fatty and Ceccato, Adrián and Ferrer, Ricard and Motos, Anna and Riera, Jordi and Fernández, Laia and Menéndez, Rosario and Lorente, José A. and Peñuelas, Oscar and García Gasulla, Dario and Peñasco, Yhivian and Ricart, Pilar and Abril Palomares, Elena and Aguilera, Luciano and Rodríguez, Alejandro and Boado Varela, Maria Victoria and Beteré, Belén and Pozo-Laderas, Juan Carlos and Solé Violán, Jordi and Salvador-Adell, Inmaculada and Andrea Novo, Mariana and Barberán, José and Amaya Villar, Rosario and Garnacho-Montero, José and Gómez, José M. and Blandino Ortiz, Aaron and Tamayo Lomas, Luis and Úbeda, Alejandro and Catalán‑González, Mercedes and Sánchez Miralles, Ángel and Gumucio-Sanguino, Víctor D. and Bustamante Munguira, Elena and Valdivia, Luis Jorge and Caballero, Jesús and Gallego, Elena and Rodríguez, Covadonga and Castellanos Ortega, Álvaro and Trenado, Josep and Marin Corral, Judith and Albaiceta, Guillermo M. and de la Torre, María del Carmen and Loza Vázquez, Ana and Vidal, Pablo and Añón, José Manuel and Carbajales Pérez, Cristina and Sagredo, Víctor and Carbonell, Nieves and Socias, Lorenzo and Barberà, Carme and Estella García, Ángel and Díaz, Emili and de Gonzalo Calvo, David and Torres, Antoni and Barbé, Ferrán and Cabello, M. A. and Alcaraz-Serrano, V. and Aldecoa, C. and Alegre, C. and Calderón, Á. A. and Álvarez, S. and Bardi, T. and Segade, P. B. and Barroso, M. and García, J.Á.B and Bermejo, J. and Bigas, J. and Blancas, R. and Cortés, M. L. B. and Saera, M.B. and Bofill, N. and Vieiro, M.T.B. and Bueno, L. and Bustamante Munguira, Juan and Martínez, C. B. D. and Hermoso, D. C. and Fernández, S.C. and Cano, I. and Canseco, J. and Fernández, P. C. and García, L. C. and Carvalho, S. and Castellà, M. and Castellví, A. and Castro, P. and Centelles-Serrano, M.J. and Ávila, R.C. and Cillóniz, C. and Clar, L. and Climent, C. and Codina, J. and Conde, P. and Contreras, S. and Parra, R.D.F. and Sánchez, R.D.P. and Mendoza, D.D. and Díaz, Y. and Vilas, M.D.R. and Moreno, C.D. and Dot, I. and Giraudo, P.E. and Arijón, I.E. and Monjo, T.F. and Fernández, J. and Ferrando, C. and Figueras, A. and Gomà, G. and Casal, V.G. and Gómez, S. and Gonzalez, C.G. and Gordo, F. and Gracia, M.P. and Fernández, M.J.G. and Herraiz, A. and Herrán-Monge, R. and Ibarz, M. and Iglesias, S. and Mantellini, C. L. and Naya, G. M. and Barcos, I. M. and Marcos, P. and Peis, E. M. and Cuadrado, M. M. and Delgado, M. C. M. and Vicente, P. M. and Martínez, P. M. and Fernández, C.E.M. and Juan, M. D. M. and Palacios, B.M. and Jiménez, J. F. M. and Masclans, J. R. and Maseda, E. and Fernández, E. M. M. and Banderas, P. M. and Mínguez, O. and Miralbés, M. and Monclou, J. and Montejo-González, J. C. and Montserrat, N. and Aznar, M. M. and Morales, D. and Cano, S.G.M. and Rodríguez, D. M. and Muñoz-Bermúdez, R. and Nicolás, J.M. and Bou, R.N. and Salinas, R.N. and Ocón, M. and Ortega, A. and Ossa, S. and Pagliarani, P. and Parrilla, F. and Pedregosa-Díaz, J. and Bastida, L. P. and Pérez, P. and Pérez-García, F. and Planelles, G. P. and Rubio, E. P. and Laguna, D.P. and Prados, J. and Pujol, A. and Coll, N. R. and Sánchez-Girón, G.R. and Roche-Campo, F. and Rodríguez, L. and Castro, F. R. D. and Rodríguez, S. and Ruiz, C. R. and Rubio, J. and Pensado, M. S. and Serra, L. and Serra-Fortuny, M. and Lázaro, A. S. and Servià, L. and Soliva, L. and Speziale, C. and Tormos, A. and Torres, M. and Tranque-Liberal, C. and Trefler, S. and Trujillano, J. and Vaca, R. and Val, E. and Ruiz, L. V. and Vallverdú, M. and Martín-Montalvo, M. V. D. H. and Adrio, S.V. and Vázquez, N. and Vengoechea, J. and Vilà-Vilardel, C. and Vilanova, J. and Warrington, T.V. and Yang, H. and Yang, M. and Zapatero, A.},
}