@misc{10498/32025,
year = {2023},
url = {http://hdl.handle.net/10498/32025},
abstract = {Background. The aim of this study was to investigate the incidence of COVID-19-associated
pulmonary aspergillosis (CAPA) in critically ill patients and the impact of anticipatory antifungal
treatment on the incidence of CAPA in critically ill patients. Methods. Before/after observational
study in a mixed intensive care unit (ICU) of a university teaching hospital. The study took place
between March 2020 and June 2022. Inclusion criteria were critically ill patients with severe SARSCoV-
2 pneumonia requiring invasive mechanical ventilation. Two analysis periods were compared
according to whether or not antifungal therapy was given early. Results. A total of 160 patients with
severe SARS-CoV-2 pneumonia and invasive mechanical ventilation were included. The incidence
of CAPA in the first study period was 19 out of 58 patients (32.75%); during the second period,
after implementation of the intervention (anticipatory antifungal therapy), the incidence of CAPA
decreased to 10.78% (11 out of 102 patients). In patients with CAPA under invasive mechanical
ventilation, the mortality rate decreased from 100% to 64%. Conclusions. Anticipating antifungal
treatment in patients with SARS-CoV-2 pneumonia under invasive mechanical ventilation was
associated with a decrease in the incidence and mortality of pulmonary aspergillosis.},
publisher = {MDPI},
keywords = {SARS-CoV-2},
keywords = {liposomal amphotericin B},
keywords = {ARDS},
keywords = {aspergillus},
keywords = {bronchoalveolar lavage},
keywords = {ICU},
title = {Anticipatory Antifungal Treatment in Critically Ill Patients with SARS-CoV-2 Pneumonia},
doi = {10.3390/JOF9030288},
author = {Estella García, Angel and Recuerda Núñez, María and Lagares Franco, Carolina María and Gracia Romero, Manuel Angel and Torres, Eva and Alados Arboledas, Juan Carlos and Antón Escors, Álvaro and González García, Clara and Sandar Núñez, Dolores and López Prieto, Dolores and Sánchez Calvo, Juan Manuel},
}