@misc{10498/32319,
year = {2023},
url = {http://hdl.handle.net/10498/32319},
abstract = {Objectives: HIV infection has been associated with lower rates of sustained viral response (SVR) with direct-acting antivirals (DAAs). There are few data on glecaprevir/pibrentasvir (G/P) in HIV/HCV coinfection outside clinical trials. Methods: The HEPAVIR-DAA cohort, which recruits HIV/HCV-coinfected patients (NCT02057003) and the GEHEP-MONO cohort (NCT02333292), including HCV-monoinfected individuals, are two concurrent ongoing multicentre cohorts of patients receiving anti-HCV treatment. Patients starting G/P included in those cohorts were analysed. Overall SVR (ITT), discontinuations due to adverse effects, and dropouts were evaluated and compared between both cohorts. Results: Of the 644 patients who started G/P with evaluable SVR, 132 were HIV/HCV coinfected. Overall SVR rates were 487/512 (95.1%) in HCV-monoinfected patients versus 126/132 (95.5%) in HIV/HCV-coinfected patients (P = 1.000). One patient (0.8%) relapsed, and another (0.8%) discontinued treatment due to side effects. SVR to 8 or 12 weeks of treatment with G/P was similar in HIV/HCV-coinfected versus HCV-monoinfected patients. The main reason for not reaching SVR among HIV/HCV-coinfected patients was premature dropout linked to active drug use. Conclusions: G/P in HIV/HCV coinfection was highly effective and tolerable in clinical practice. SVR to 8 or 12 weeks of treatment with G/P was similar in HIV/HCV-coinfected compared with HCV-monoinfected patients but active drug use is still a barrier to reach HCV microelimination.},
publisher = {Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy},
title = {Response to glecaprevir/pibrentasvir in HIV/HCV-coinfected patients in clinical practice},
doi = {https://doi.org/10.1093/JAC/DKAD278},
author = {Gonzalez-Serna, Alejandro and Corma-Gomez, Anaïs and Téllez Pérez, Francisco de Paula and Corona-Mata, Diana and Rios-Villegas, María Jose and Merino, Dolores and Galera, Carlos and Collado-Romacho, Antonio Ramon and De Los Santos, Ignacio and Cucurull, Josep and Santos, Marta and García-Martín, Sofía and Rivero, Antonio and Real, Luis Miguel and Macias, Juan},
}