@misc{10498/32760,
year = {2024},
url = {http://hdl.handle.net/10498/32760},
abstract = {BACKGROUND: The corpus callosum (CC) is suggested as an indirect biomarker of white matter volume, which is often affected in
preterm birth. However, diagnosing mild white matter injury is challenging.
METHODS: We studied 124 children born preterm (mean age: 8.4 ± 1.1 years), using MRI to assess CC measurements and cognitive/
motor outcomes based on the Wechsler Intelligence Scale for Children-V (WPPSI-V) and Movement Assessment Battery for
Children-2 (MABC-2).
RESULTS: Children with normal outcomes exhibited greater height (10.2 ± 2.1 mm vs. 9.4 ± 2.3 mm; p = 0.01) and fractional
anisotropy at splenium (895[680–1000] vs 860.5[342–1000]) and total CC length (69.1 ± 4.8 mm vs. 67.3 ± 5.1 mm; p = 0.02)
compared to those with adverse outcomes. All measured CC areas were smaller in the adverse outcome group. Models
incorporating posterior CC measurements demonstrated the highest specificity (83.3% Sp, AUC: 0.65) for predicting neurological
outcomes. CC length and splenium height were the only linear measurements associated with manual dexterity and total MABC-2
score while both the latter and genu were related with Full-Scale Intelligence Quotient.
CONCLUSIONS: CC biometry in children born very preterm at school-age is associated with outcomes and exhibits a specific
subregion alteration pattern. The posterior CC may serve as an important neurodevelopmental biomarker in very preterm infants.},
organization = {Ministerio de Ciencia, Innovación y Universidades (España)
European Commission (Unión Europea)
Instituto de Salud Carlos III (España)
Fondos europeos de desarrollo regional (Unión Europea)},
publisher = {Springer Nature},
title = {Corpus callosum long-term biometry in very preterm children related to cognitive and motor outcomes},
doi = {10.1038/s41390-023-02994-4},
author = {Lubián Gutiérrez, Manuel and Benavente Fernández, Isabel and Marín-Almagro, Y. and Jiménez Luque, Natalia and Zuazo Ojeda, Mirem Amaya and Sánchez Sandoval, Yolanda and Lubián López, Simón Pedro},
}