@misc{10498/33429,
year = {2018},
url = {http://hdl.handle.net/10498/33429},
abstract = {Striatal locally projecting neurons, or interneurons, act on nearby circuits and shape functional output to the rest of the basal ganglia. We performed sin- gle-cell RNA sequencing of striatal cells enriching for interneurons. We find seven discrete interneuron types, six of which are GABAergic. In addition to providing specific markers for the populations previ- ously described, including those expressing Sst/Npy, Th, Npy without Sst, and Chat, we identify two small populations of cells expressing Cck with or without Vip. Surprisingly, the Pvalb-expressing cells do not constitute a discrete cluster but rather are part of a larger group of cells expressing Pthlh with a spatial gradient of Pvalb expression. Using PatchSeq, we show that Pthlh cells exhibit a continuum of electro- physiological properties correlated with expression of Pvalb. Furthermore, we find significant molecular differences that correlate with differences in electro- physiological properties between Pvalb-expressing cells of the striatum and those of the cortex.},
publisher = {Cell Press},
keywords = {Pthlh},
keywords = {cell classes},
keywords = {cortex},
keywords = {electrophysiology},
keywords = {fast-spiking neurons},
keywords = {interneuron},
keywords = {parvalbumin},
keywords = {single-cell RNA sequencing},
keywords = {striatum},
title = {Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq},
doi = {10.1016/j.celrep.2018.07.053},
author = {Muñoz Manchado, Ana Belen and Bengtsson Gonzales, C. and Zeisel, A. and Munguba, H. and Bekkouche, B. and Skene, N.G. and Lönnerberg, P. and Ryge, J. and Harris, K.D. and Linnarsson, S. and Hjerling-Leffler, Jens},
}