@misc{10498/33638,
year = {2024},
url = {http://hdl.handle.net/10498/33638},
abstract = {Background: Klebsiella aerogenes has been reclassified from Enterobacter to Klebsiella genus due to its phenotypic and genotypic similarities with Klebsiella pneumoniae. It is unclear if clinical outcomes are also more similar. This study aims to assess clinical outcomes of bloodstreams infections (BSI) caused by K. aerogenes, K. pneumoniae and Enterobacter cloacae, through secondary data analysis, nested in PRO-BAC cohort study. Methods: Hospitalized patients between October 2016 and March 2017 with monomicrobial BSI due to K. aerogenes, K. pneumoniae or E. cloacae were included. Primary outcome was a composite clinical outcome including all-cause mortality or recurrence until 30 days follow-up. Secondary outcomes were fever ≥ 72 h, persistent bacteraemia, and secondary device infection. Multilevel mixed-effect Poisson regression was used to estimate the association between microorganisms and outcome. Results: Overall, 29 K. aerogenes, 77 E. cloacae and 337 K. pneumoniae BSI episodes were included. Mortality or recurrence was less frequent in K. aerogenes (6.9%) than in E. cloacae (20.8%) or K. pneumoniae (19.0%), but statistical difference was not observed (rate ratio (RR) 0.35, 95% CI 0.08 to 1.55; RR 0.42, 95% CI 0.10 to 1.71, respectively). Fever ≥ 72 h and device infection were more common in K. aerogenes group. In the multivariate analysis, adjusted for confounders (age, sex, BSI source, hospital ward, Charlson score and active antibiotic therapy), the estimates and direction of effect were similar to crude results. Conclusions: Results suggest that BSI caused by K. aerogenes may have a better prognosis than E. cloacae or K. pneumoniae BSI. © The Author(s) 2024.},
publisher = {BioMed Central Ltd},
keywords = {Bloodstream infection},
keywords = {Enterobacter cloacae},
keywords = {Klebsiella aerogenes},
keywords = {Klebsiella pneumoniae},
keywords = {Mortality},
keywords = {Recurrence},
title = {Differences in clinical outcomes of bloodstream infections caused by Klebsiella aerogenes, Klebsiella pneumoniae and Enterobacter cloacae: a multicentre cohort study},
author = {Guedes, Mariana and Gathara, David and López Hernández, Inmaculada and Martínez Pérez-Crespo, Pedro María and Pérez Rodríguez, María Teresa and Sousa, Adrian and Plata, Antonio and Reguera Iglesias, José María and Boix Palop, Lucía and Dietl, Beatriz and Blanco, Juan Sevilla and Castillo, Carlos Armiñanzas and Galán Sanchez, Fátima and Kindelán, Clara Natera and Jóver Saenz, Alfredo and Aguirre, Josune Goikoetxea and Alemán, Ana Alemán and Marrodán Ciordia, Teresa and del Arco Jiménez, Alfonso and Fernández Suárez, Jonathan and López Cortés, Luis Eduardo and Rodríguez Baño, Jesús},
}